Recombinant Human Tumor necrosis factor receptor superfamily member 17 protein (TNFRSF17), partial (Active) | CSB-AP002271HU

Recombinant Human Tumor necrosis factor receptor superfamily member 17 protein (TNFRSF17) ,partial (Active) | CSB-AP002271HU | Cusabio

Protein Description: Partial

Alternative Name (s) : B-cell maturation protein,

Gene Names: TNFRSF17,BCM,BCMA

Research Areas: Cancer

Species: Homo sapiens (Human)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: 5-54aa

Sequence Info: AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated murine B cells is no less than 40 ng/ml, corresponding to a specific activity of ＞ 2.5 × 104 IU/mg in the presence of 100 ng/ml human APRIL.

MW: 5.4 kDa

Purity: >98% as determined by SDS-PAGE and HPLC.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733, ECO:0000269|PubMed:10973284}.

PubMed ID: 1396583; 8165126; 11528522; 17825416; 10493829; 15616553; 10903733; 10801128; 10973284; 10908663; 12721620; 15542592

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Involvement in disease: A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL) . Translocation t (4;16) (q26;p13) with IL2.

Subcellular Location: Cell membrane, Single-pass type III membrane protein, Endomembrane system, Single-pass type III membrane protein

Protein Families:

Tissue Specificity: Expressed in mature B-cells, but not in T-cells or monocytes.

Paythway:

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 μm filtered 30 % acetonitrile, 0.1 % TFA

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q02223

Uniprot Entry Name: TNR17_HUMAN

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM