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RPTOR Antibody | CSB-PA839774LA01HU

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SKU:
CSB-PA839774LA01HU
Availability:
3 to 7 Working Days
  • RPTOR Antibody
  • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA839774LA01HU at dilution of 1:100
  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA839774LA01HU at dilution of 1:100
  • Immunofluorescent analysis of Hela cells using CSB-PA839774LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L)
€315.80 - €488.70
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Description

RPTOR Antibody | CSB-PA839774LA01HU | Cusabio

RPTOR Antibody is Available at Gentaur Genprice with the fastest delivery.

Online Order Payment is possible or send quotation to [email protected]

Product Type: Polyclonal Antibody

Target Names: RPTOR

Aliases: Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR) -scaffold protein), RPTOR, KIAA1303 RAPTOR

Background: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E) . mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q8N122

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Regulatory-associated protein of mTOR protein (13-128AA)

Immunogen Species: Human

Applications: ELISA, IHC, IF

Tested Applications: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:20-1:200

Dilution Ratio3: IF:1:50-1:200

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Epigenetics & Nuclear Signaling;Cell biology;Signal transduction

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