RPTOR Antibody, FITC conjugated | CSB-PA839774LC01HU
- 3 to 7 Working Days
RPTOR Antibody, FITC conjugated | CSB-PA839774LC01HU | Cusabio
RPTOR Antibody, FITC conjugated is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: RPTOR
Aliases: Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR) -scaffold protein), RPTOR, KIAA1303 RAPTOR
Background: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E) . mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.
Uniport ID: Q8N122
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human Regulatory-associated protein of mTOR protein (13-128AA)
Immunogen Species: Human
Tested Applications: ELISA
Purification Method: >95%, Protein G purified
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Cell Biology
Research Areas: Epigenetics & Nuclear Signaling;Cell biology;Signal transduction