RGS14 Antibody | CSB-PA077027

RGS14 Antibody | CSB-PA077027 | Cusabio

RGS14 Antibody is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: RGS14

Aliases: regulator of G-protein signaling 14; RGSE;

Background: Acts as a regulator of G protein signaling (RGS) . Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI) . Confers GDI activity on G (i) alpha subunits GNAI1 and GNAI3, but not G (o) alpha subunit GNAO1 and G (i) alpha subunit GNAI2. Confers GAP activity on G (o) alpha subunit GNAI0 and G (i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF) -stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G (i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G (i) -alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF) -mediated neurite outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory.

Lopez-Aranda M.F., Eur. J. Neurosci. 23:2971-2982 (2006) .
Chatterjee T.K., Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
Puhl H.L. III, Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: O43566

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Synthesized peptide derived from internal of human RGS14.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:3000

Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:3000

Dilution Ratio3:

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Dilution Ratio6:

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Signal transduction