RGS14 Antibody | CSB-PA019646ESR1HU

RGS14 Antibody | CSB-PA019646ESR1HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: RGS14

Aliases: Regulator of G-protein signaling 14 (RGS14), RGS14

Background: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI) . Has GDI activity on G (i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G (o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF) -stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G (i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G (i) -alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF) -mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: O43566

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Regulator of G-protein signaling 14 protein (230-510AA)

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

Purification Method: Antigen Affinity Purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:1000-1:5000

Dilution Ratio3:

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Signal transduction