Recombinant Mouse Prohibitin (Phb), partial | CSB-EP017885MO1
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Recombinant Mouse Prohibitin (Phb), partial | CSB-EP017885MO1 | Cusabio
Alternative Name(s): B-cell receptor-associated protein 32 (BAP 32)
Gene Names: Phb
Research Areas: Cancer
Organism: Mus musculus (Mouse)
AA Sequence: MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFD
Tag Info: N-terminal 6xHis-tagged
Expression Region: 1-40aa
Sequence Info: Partial
MW: 8.1 kDa
Purity: Greater than 85% as determined by SDS-PAGE.
Relevance: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
Reference: "Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence." Coates P.J., Nenutil R., McGregor A., Picksley S.M., Crouch D.H., Hall P.A., Wright E.G. Exp. Cell Res. 265:262-273(2001)
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity).
Involvement in disease:
Subcellular Location: Mitochondrion inner membrane
Protein Families: Prohibitin family
Tissue Specificity: Widely expressed in different tissues.
Form: Liquid or Lyophilized powder
Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: P67778
HGNC Database Link: N/A
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: N/A