Recombinant Mouse Fractalkine protein (Cx3cl1) (Active) | CSB-AP001211MO

Recombinant Mouse Fractalkine protein (Cx3cl1) (Active) | CSB-AP001211MO | Cusabio

Protein Description: Partial

Alternative Name (s) : C-X3-C motif chemokine 1, Neurotactin, Small-inducible cytokine D1, ,

Gene Names: Cx3cl1,Cx3c,Fkn,Scyd1

Research Areas: Immunology

Species: Mus musculus (Mouse)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: 25-100aa

Sequence Info: QHLGMTKCEI MCGKMTSRIP VALLIRYQLN QESCGKRAIV LETTQHRRFC ADPKEKWVQD AMKHLDHQAA ALTKNG

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human peripheral blood lymphocytes (PBL) is less than 0.5 μg/ml, corresponding to a specific activity of ＞ 2000 IU/mg.

MW: 8.7 kDa

Purity: >97% as determined by SDS-PAGE and HPLC.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (By similarity) . Binds to CX3CR1. {ECO:0000250}.

PubMed ID: 9177350; 9479488; 10382755; 16141072; 15489334; 9845323; 21183079

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV

Involvement in disease:

Subcellular Location: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Processed fractalkine: Secreted

Protein Families: Intercrine delta family

Tissue Specificity: Highest levels in brain. Lower levels in kidney, heart and lung. Also found in skeletal muscle and testis.

Paythway:

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: O35188

Uniprot Entry Name: X3CL1_MOUSE

HGNC Database Link: N/A

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: N/A