Recombinant Rat Fractalkine protein (Cx3cl1) (Active) | CSB-AP001511RA
- 5 to 10 Working Days
Recombinant Rat Fractalkine protein (Cx3cl1) (Active) | CSB-AP001511RA | Cusabio
Protein Description: Partial
Alternative Name (s) : C-X3-C motif chemokine 1, Neurotactin, Small-inducible cytokine D1, ,
Gene Names: Cx3cl1,Acc1,Fkn,Scyd1
Research Areas: Immunology
Species: Rattus norvegicus (Rat)
Tag Info: Tag-Free
Expression Region: 25-100aa
Sequence Info: QHLGMTKCNI TCHKMTSPIP VTLLIHYQLN QESCGKRAII LETRQHRHFC ADPKEKWVQD AMKHLDHQTA ALTRNG
Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration of 5.0-10 ng/ml.
MW: 8.8 kDa
Purity: >95% as determined by SDS-PAGE and HPLC.
Endotoxin: Less than 1.0 EU/µg as determined by LAL method.
Relevance: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.
PubMed ID: 9724801
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Function: Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV
Involvement in disease:
Subcellular Location: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Processed fractalkine: Secreted
Protein Families: Intercrine delta family
Tissue Specificity: Highest levels in brain (neurons) . Significant levels in kidney, heart, lung and adrenal gland.
Form: Lyophilized powder
Buffer: Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: O55145
Uniprot Entry Name: X3CL1_RAT
HGNC Database Link: N/A
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: N/A