Recombinant Mouse CB1 cannabinoid receptor-interacting protein 1 (Cnrip1) | CSB-YP705797MO
- 25 - 35 Working Days
Recombinant Mouse CB1 cannabinoid receptor-interacting protein 1 (Cnrip1) | CSB-YP705797MO | Cusabio
Alternative Name(s): Cnrip1CB1 cannabinoid receptor-interacting protein 1; CRIP-1
Gene Names: Cnrip1
Research Areas: Neuroscience
Organism: Mus musculus (Mouse)
AA Sequence: MGDLPGLVRLSIALRIQPNDGPVFFKVDGQRFGQNRTIKLLTGSSYKVEVKIKPTTLQVENISIGGVLVPLELKGKEPDGERVVYTGIYDTEGVAPTKSGERQPIQITMPFTDIGTFETVWQVKFYNYHKRDHCQWGSPFSVIEYECKPNETRSLMWVNKESFL
Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged
Expression Region: 1-464aa
Sequence Info: Full Length
MW: 22.6 kDa
Purity: Greater than 85% as determined by SDS-PAGE.
Relevance: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.
Reference: "CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a." Niehaus J.L., Liu Y., Wallis K.T., Egertova M., Bhartur S.G., Mukhopadhyay S., Shi S., He H., Selley D.E., Howlett A.C., Elphick M.R., Lewis D.L. Mol. Pharmacol. 72:1557-1566(2007)
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.
Involvement in disease:
Protein Families: CNRIP family
Tissue Specificity: Highly expressed in brain. Also detected in heart, lung, intestine, kidney, testis, spleen, liver and muscle (at protein level).
Form: Liquid or Lyophilized powder
Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: Q5M8N0
HGNC Database Link: N/A
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: N/A
OMIM Database Link: N/A