Recombinant Human Thymosin beta-4 (TMSB4X) (Active) | CSB-AP000381HU

Recombinant Human Thymosin beta-4 (TMSB4X) (Active) | CSB-AP000381HU | Cusabio

Protein Description: Full Length of Mature Protein

Alternative Name (s) : T beta-4,

Gene Names: TMSB4X,TB4X,THYB4,TMSB4

Research Areas: Signal Transduction

Species: Homo sapiens (Human)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: 2-44aa

Sequence Info: SDKPDMAEIE KFDKSKLKKT ETQEKNPLPS KETIEQEKQA GES

Biological Activity: Fully biologically active when compared to standard. The biological activity determined by its ability to produce a protective effect against hydrogen peroxide in primary lung fibroblasts is in a concentration range of 0.5 - 10 μg/ml.

MW: 4.9 kDa

Purity: >97% as determined by SDS-PAGE and HPLC.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: Plays an important role in the organization of the cytoskeleton (By similarity) . Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. {ECO:0000250}.; Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. {ECO:0000250}.

PubMed ID: 3500230; 16010977; 1999398; 6548414; 18669648; 19608861; 20068231; 21269460; 21406692; 22223895; 10848969; 23009842

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: Plays an important role in the organization of the cytoskeleton (By similarity) . Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.

Involvement in disease:

Subcellular Location: Cytoplasm, cytoskeleton

Protein Families: Thymosin beta family

Tissue Specificity: Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells.

Paythway: Regulationofactincytoskeleton

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 µm filtered concentrated solution in 20 mM PB, pH 7.4.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P62328

Uniprot Entry Name: TYB4_HUMAN

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM