Recombinant Human Thioredoxin, mitochondrial (TXN2) | CSB-EP857458HU
- 13 - 23 Working Days
Recombinant Human Thioredoxin, mitochondrial (TXN2) | CSB-EP857458HU | Cusabio
Alternative Name(s): Thioredoxin-2
Gene Names: TXN2
Research Areas: Signal Transduction
Organism: Homo sapiens (Human)
AA Sequence: TTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG
Tag Info: N-terminal GST-tagged
Expression Region: 1-166aa
Sequence Info: Full Length
MW: 38.9 kDa
Purity: Greater than 90% as determined by SDS-PAGE.
Relevance: Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.
Reference: "Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells." Chen Y., Cai J., Murphy T.J., Jones D.P. J. Biol. Chem. 277:33242-33248(2002)
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function: Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.
Involvement in disease: Combined oxidative phosphorylation deficiency 29 (COXPD29)
Subcellular Location: Mitochondrion
Protein Families: Thioredoxin family
Tissue Specificity: Widely expressed in adult (at protein level) and fetal tissues.
Form: Liquid or Lyophilized powder
Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: Q99757
HGNC Database Link: HGNC
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: OMIM