Cusabio Human Recombinants
Recombinant Human Sialidase-3 (NEU3), partial | CSB-EP891986HU
- SKU:
- CSB-EP891986HU
- Availability:
- 13 - 23 Working Days
Description
Recombinant Human Sialidase-3 (NEU3), partial | CSB-EP891986HU | Cusabio
Alternative Name(s): Ganglioside sialidase;Membrane sialidaseN-acetyl-alpha-neuraminidase 3
Gene Names: NEU3
Research Areas: Metabolism
Organism: Homo sapiens (Human)
AA Sequence: EEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLVLRRGLRIGQLVQWGPLKPLMEATLPGHRTMNPCPVWEQKSGCVFLFFICVRGHVTERQQIVSGRNAARLCFIYSQDAGCSWSEVRDLTEEVIGSELKHWATFAVGPGHGIQLQSGRLVIPAYTYYIPSWFFCFQLPCKTRPHSLMIYSDDLGVTWHHGRLIRPMVTVECEVAEVTGRAGHPVLYCSARTPNRCRAEALSTDHGEGFQRLALSRQLCEPPHGCQGSVVSFRPLEIPHRCQDSSSKDAPTIQQSSPGSSLRLEEEAGTPSESWLLYSHPTSRKQRVDLGIYLNQTPLEAACWSRPWILHCGPCGYSDLAALEEEGLFGCLFECGTKQECEQIAFRLFTHREILSHLQGDCTSPGRNPSQFKSN
Source: E.coli
Tag Info: N-terminal 6xHis-tagged
Expression Region: 2-428aa
Sequence Info: Partial
MW: 52.1 kDa
Purity: Greater than 90% as determined by SDS-PAGE.
Relevance: Plays a role in modulating the ganglioside content of the lipid bilayer at the level of mbrane-bound sialyl glycoconjugates.
Reference: Cloning, expression, and chromosomal mapping of a human ganglioside sialidase.Wada T., Yoshikawa Y., Tokuyama S., Kuwabara M., Akita H., Miyagi T.Biochem. Biophys. Res. Commun. 261:21-27(1999)
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function: Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.
Involvement in disease:
Subcellular Location: Cell membrane, Peripheral membrane protein
Protein Families: Glycosyl hydrolase 33 family
Tissue Specificity: Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung.
Paythway:
Form: Liquid or Lyophilized powder
Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: Q9UQ49
HGNC Database Link: HGNC
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: OMIM