Recombinant Human Ribosomal protein S6 kinase beta-2 (RPS6KB2), partial | CSB-RP029054h

Recombinant Human Ribosomal protein S6 kinase beta-2 (RPS6KB2), partial | CSB-RP029054h | Cusabio

Alternative Name(s): 70KDA ribosomal protein S6 kinase 2 ;P70S6K2 ;p70-S6K 2S6 kinase-related kinase ;SRKSerine/threonine-protein kinase 14Bp70 ribosomal S6 kinase beta ;S6K-beta ;p70 S6 kinase beta ;p70 S6K-beta ;p70 S6KB ;p70-beta

Gene Names: RPS6KB2

Research Areas: Signal Transduction

Organism: Homo sapiens (Human)

AA Sequence: MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKL

Source: E.coli

Tag Info: N-terminal GST-tagged

Expression Region: 1-210aa

Sequence Info: Partial

MW: 50.2 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Phosphorylates specifically ribosomal protein S6.

Reference: Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.Gout I., Minami T., Hara K., Tsujishita Y., Filonenko V., Waterfield M.D., Yonezawa K.J. Biol. Chem. 273:30061-30064(1998)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Phosphorylates specifically ribosomal protein S6.

Involvement in disease:

Subcellular Location: Cytoplasm, Nucleus

Protein Families: Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily

Tissue Specificity:

Paythway: ErbBsignalingpathway

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q9UBS0

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM