Recombinant Human Methylenetetrahydrofolate reductase (MTHFR) | CSB-YP015158HU

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25 - 35 Working Days
  • Recombinant Human Methylenetetrahydrofolate reductase (MTHFR)
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
€262.00 - €1,406.00


Recombinant Human Methylenetetrahydrofolate reductase (MTHFR) | CSB-YP015158HU | Cusabio

Alternative Name(s): 5 10 methylenetetrahydrofolate reductase (NADPH); 5 10 methylenetetrahydrofolate reductase; Methylenetetrahydrofolate reductase (NAD(P)H); Methylenetetrahydrofolate reductase; Methylenetetrahydrofolate reductase intermediate form; MTHFR; MTHR_HUMAN

Gene Names: MTHFR

Research Areas: Metabolism

Organism: Homo sapiens (Human)


Source: Yeast

Tag Info: N-terminal 6xHis-tagged

Expression Region: 1-656aa

Sequence Info: Full Length

MW: 76.6 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.

Reference: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project Team Genome Res. 14:2121-2127(2004)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.

Involvement in disease: Methylenetetrahydrofolate reductase deficiency (MTHFRD); Ischemic stroke (ISCHSTR); Neural tube defects, folate-sensitive (NTDFS); Schizophrenia (SCZD)

Subcellular Location:

Protein Families: Methylenetetrahydrofolate reductase family

Tissue Specificity:


Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P42898

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM

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