Recombinant Human Islet amyloid polypeptide (IAPP), partial | CSB-YP010931HU

Recombinant Human Islet amyloid polypeptide (IAPP), partial | CSB-YP010931HU | Cusabio

Alternative Name(s): PYY-I

Gene Names: IAPP

Research Areas: Signal Transduction

Organism: Homo sapiens (Human)

AA Sequence: KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY

Source: Yeast

Tag Info: N-terminal 6xHis-tagged

Expression Region: 34-70aa

Sequence Info: Partial

MW: 5.9 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

Reference: The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR.Nygaard R., Nielbo S., Schwartz T.W., Poulsen F.M.Biochemistry 45:8350-8357(2006)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

Involvement in disease:

Subcellular Location: Secreted

Protein Families: Calcitonin family

Tissue Specificity:

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P10997

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM