Recombinant Human Interleukin-2 protein (IL2) (Active) | CSB-AP001691HU

Recombinant Human Interleukin-2 protein (IL2) (Active) | CSB-AP001691HU | Cusabio

Protein Description: Full Length of Mature Protein

Alternative Name (s) : IL-2, TCGF, Aldesleukin

Gene Names: IL2

Research Areas: Immunology

Species: Homo sapiens (Human)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: 21-153aa

Sequence Info: APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.1 ng/ml, corresponding to a specific activity of ＞ 1.0 × 107 IU/mg.

MW: 15.4 kDa

Purity: >97% as determined by SDS-PAGE and HPLC.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

PubMed ID: 6312994; 6403867; 6306584; 6324170; 6330695; 6608729; 7722480; 8824916; 15489334; 3491296; 3264184; 6333684; 2793860; 3500515; 1631562; 1510960; 7529123; 16293754; 16477002

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Involvement in disease: A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL) . Translocation t (4;16) (q26;p13) with involves TNFRSF17.

Subcellular Location: Secreted

Protein Families: IL-2 family

Tissue Specificity:

Paythway: Jak-STATsignalingpathway

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 μm filtered 20 mM PB, pH 3.5

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P60568

Uniprot Entry Name: IL2_HUMAN

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM