Cusabio Human Recombinants
Recombinant Human Interleukin-2 (IL2) | CSB-EP011629HU
- 13 - 23 Working Days
Recombinant Human Interleukin-2 (IL2) | CSB-EP011629HU | Cusabio
Alternative Name(s): T-cell growth factor ;TCGFINN: Aldesleukin
Gene Names: IL2
Research Areas: Immunology
Organism: Homo sapiens (Human)
AA Sequence: APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
Tag Info: N-terminal GST-tagged
Expression Region: 21-153aa
Sequence Info: Full Length of Mature Protein
MW: 42.4 kDa
Purity: Greater than 90% as determined by SDS-PAGE.
Relevance: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Reference: Crystal structure of the IL-2 signaling complex paradigm for a heterotrimeric cytokine receptor.Stauber D.J., Debler E.W., Horton P.A., Smith K.A., Wilson I.A.Proc. Natl. Acad. Sci. U.S.A. 103:2788-2793(2006)
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Involvement in disease: A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Subcellular Location: Secreted
Protein Families: IL-2 family
Form: Liquid or Lyophilized powder
Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: P60568
HGNC Database Link: HGNC
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: OMIM