Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) | CSB-YP006045HU

Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) | CSB-YP006045HU | Cusabio

Alternative Name(s): Colony-stimulating factor Short name: CSF Molgramostin Sargramostim

Gene Names: CSF2

Research Areas: Immunology

Organism: Homo sapiens (Human)

AA Sequence: APARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE

Source: Yeast

Tag Info: N-terminal 6xHis-tagged

Expression Region: 18-144aa

Sequence Info: Full Length of Mature Protein

MW: 16.5 kDa

Purity: Greater than 90% as determined by SDS-PAGE.

Relevance: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

Reference: "Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor."Cantrell M.A., Anderson D., Cerretti D.P., Price V., McKereghan K., Tushinski R.J., Mochizuki D.Y., Larsen A., Grabstein S., Gillis S., Cosman D.Proc. Natl. Acad. Sci. U.S.A. 82:6250-6254(1985)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

Involvement in disease:

Subcellular Location: Secreted

Protein Families: GM-CSF family

Tissue Specificity:

Paythway: Jak-STATsignalingpathway

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P04141

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM