Recombinant Human Fractalkine protein (CX3CL1) (Active) | CSB-AP000801HU

Recombinant Human Fractalkine protein (CX3CL1) (Active) | CSB-AP000801HU | Cusabio

Protein Description: Partial

Alternative Name (s) : C-X3-C motif chemokine 1, Neurotactin, Small-inducible cytokine D1, ,

Gene Names: CX3CL1,FKN,NTT,SCYD1,A-152E5.2

Research Areas: Immunology

Species: Homo sapiens (Human)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: 25-100aa

Sequence Info: QHHGVTKCNI TCSKMTSKIP VALLIHYQQN QASCGKRAII LETRQHRLFC ADPKEQWVKD AMQHLDRQAA ALTRNG

Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration of 5.0-10 ng/ml.

MW: 8.6 kDa

Purity: >97% as determined by SDS-PAGE and HPLC.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. {ECO:0000269|PubMed:21829356}.

PubMed ID: 9024663; 10493829; 15489334; 19838169; 22171320; 9931005; 10770945; 21829356

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1

Involvement in disease:

Subcellular Location: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Processed fractalkine: Secreted

Protein Families: Intercrine delta family

Tissue Specificity: Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level) . Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Most abundant in the brain and heart.

Paythway: Chemokinesignalingpathway

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P78423

Uniprot Entry Name: X3CL1_HUMAN

HGNC Database Link: HGNC

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: OMIM