Recombinant Human Carbonic anhydrase 5B, mitochondrial (CA5B) (Active) | CSB-AP005641HU
- 5 to 10 Working Days
Recombinant Human Carbonic anhydrase 5B, mitochondrial (CA5B) (Active) | CSB-AP005641HU | Cusabio
Protein Description: Full Length of Mature Protein
Alternative Name (s) : Carbonic Anhydrase 5B Mitochondrial; Carbonate Dehydratase VB; Carbonic Anhydrase VB; CA-VB; CA5B
Gene Names: CA5B
Research Areas: Signal Transduction
Species: Homo sapiens (Human)
Tag Info: C-terminal 6xHis-tagged
Expression Region: 34-317aa
Sequence Info: CSLYTCTYKTRNRALHPLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNVQAKPKPATSQATP
Biological Activity: The esterase activity is determined to be greater than 1000 pmol/min/ug
MW: 33.77 kDa
Purity: Greater than 95% as determined by SDS-PAGE.
Endotoxin: Less than 1.0 EU/µg as determined by LAL method.
Relevance: Carbonic Anhydrase 5B (CA5B) is a member of alpha-carbonic anhydrase family (CAs) that catalyze the reversible hydration of carbon dioxide. CAs is associated with many biological processes, including calcification, respiration, bone resorption, acid-base balance and the formation of aqueous humor. CA5B is highly expressed in heart, pancreas, kidney, placenta, lung, and skeletal muscle, but it is restricted to the liver. CA5B is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA-VA. CA5B is inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA) , saccharin, and Foscarnet.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Function: Reversible hydration of carbon dioxide.
Involvement in disease:
Subcellular Location: Mitochondrion
Protein Families: Alpha-carbonic anhydrase family
Tissue Specificity: Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not expressed in liver.
Buffer: 0.2 μm filtered 20 mM Tris-HCl, 100 mM NaCl, pH 8.0
Uniprot ID: Q9Y2D0
Uniprot Entry Name:
HGNC Database Link: HGNC
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: OMIM