Cusabio Recombinant Antibodies
Phospho-IRF3 (S386) Antibody | CSB-RA011818A386phHU
- 3 to 7 Working Days
Phospho-IRF3 (S386) Antibody | CSB-RA011818A386phHU | Cusabio
Phospho-IRF3 (S386) Antibody is Available at Gentaur Genprice with the fastest delivery.
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Antibody Type: Recombinant Antibody
Target Names: IRF3
Aliases: Interferon regulatory factor 3, IRF-3, IRF3
Background: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
Isotype: Rabbit IgG
Clone Number: 4H10
Uniport ID: Q14653
Species Reactivity: Human
Immunogen: A synthesized peptide derived from human Phospho-IRF3 (S386)
Tested Applications: ELISA, WB; Recommended dilution: WB:1:500-1:5000
Purification Method: Affinity-chromatography
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.