Irf3 Antibody | CSB-PA011818YA01MO
- 3 to 7 Working Days
Irf3 Antibody | CSB-PA011818YA01MO | Cusabio
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Product Type: Polyclonal Antibody
Target Names: Irf3
Aliases: Interferon regulatory factor 3 (IRF-3), Irf3
Background: Key transcriptional regulator of type I interferon (IFN) -dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
Uniport ID: P70671
Host Species: Rabbit
Species Reactivity: Mouse
Immunogen: Recombinant Mouse Interferon regulatory factor 3 protein (1-419AA)
Immunogen Species: Mouse
Tested Applications: ELISA
Purification Method: >95%, Protein G purified
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Immunology
Research Areas: Epigenetics & Nuclear Signaling;Immunology