N Antibody | CSB-PA318492LA01JAM

N Antibody | CSB-PA318492LA01JAM | Cusabio

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Product Type: Polyclonal Antibody

Target Names: N

Aliases: Nucleoprotein (Nucleocapsid protein) (Protein N), N

Background: Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) . Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity) . Interacts with host IKBKE (via Protein kinase domain) ; the interaction inhibits IKBKE kinase activity.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P14239

Host Species: Rabbit

Species Reactivity: Junin mammarenavirus

Immunogen: Recombinant Junin mammarenavirus Nucleoprotein protein (1-564AA)

Immunogen Species: Junin mammarenavirus

Applications: ELISA, WB

Tested Applications: ELISA, WB; Recommended dilution: WB:1:500-1:5000

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:5000

Dilution Ratio3:

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Others

Research Areas: Others