LAPTM4B Antibody | CSB-PA774814LA01HU

LAPTM4B Antibody | CSB-PA774814LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: LAPTM4B

Aliases: Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta), LAPTM4B

Background: Required for optimal lysosomal function (PubMed:21224396) . Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4, 5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945) . Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V) -ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567) . Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825) . Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q86VI4

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Lysosomal-associated transmembrane protein 4B protein (174-226AA)

Immunogen Species: Human

Applications: ELISA, WB, IHC, IF

Tested Applications: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:5000

Dilution Ratio3: IHC:1:500-1:1000

Dilution Ratio4: IF:1:50-1:200

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cancer

Research Areas: Cancer