human Neutrophil gelatinase-associated lipocalin protein | CSB-NP068341h

human Neutrophil gelatinase-associated lipocalin protein | CSB-NP068341h | Cusabio

Product type: Native Protein

Research areas: Immunology

Target / Protein: human Neutrophil gelatinase-associated lipocalin protein

Applications: ELISA,WB,SDS-PAGE Latex enhance immune than muddy ,calibrator ,immunogen and other possible

Biologically active: Not test

Nature: Native

Protein length: Full length protein

Species of origin: Purified from human urine

Purity: >95%(SDS-PAGE)

Relevance: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Storage Buffer: PBS, pH 7.4

Form: Liquid

Stability & Storage: Aliquot and store at -20℃ or -80℃. Avoid repeated freeze/thaw cycles.

Alias: N/A