human Neutrophil gelatinase-associated lipocalin protein | CSB-NP068341h
human Neutrophil gelatinase-associated lipocalin protein | CSB-NP068341h | Cusabio
Product type: Native Protein
Research areas: Immunology
Target / Protein: human Neutrophil gelatinase-associated lipocalin protein
Applications: ELISA,WB,SDS-PAGE Latex enhance immune than muddy ,calibrator ,immunogen and other possible
Biologically active: Not test
Protein length: Full length protein
Species of origin: Purified from human urine
Relevance: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Storage Buffer: PBS, pH 7.4
Stability & Storage: Aliquot and store at -20℃ or -80℃. Avoid repeated freeze/thaw cycles.