ZAP70 (Ab-319) Antibody | CSB-PA181899

ZAP70 (Ab-319) Antibody | CSB-PA181899 | Cusabio

ZAP70 (Ab-319) Antibody is Available at Gentaur Genprice with the fastest delivery.

Online Order Payment is possible or send quotation to info@gentaur.com.

Product Type: Polyclonal Antibody

Target Names: ZAP70

Aliases: 70 kDa zeta-associated protein; SRK; Syk-related tyrosine kinase; ZA70; ZAP-70

Background:

ZAP70 is a 70-kD tyrosine phosphoprotein that associates with the zeta chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural KILLER cells. Protein-Tyrosine Kinases (PTKs) play an integral role in T-cell activation. Stimulation of the T-cell antigen receptor results in tyrosine phosphorylation of a number of cellular substrates. One of these is the TCR-zeta chain, which can mediate the transduction of extracellular stimuli into cellular effector functions

Salomon AR, et al. (2003) Proc Natl Acad Sci U S A; 100 (2) : 443-448
Ku GM, et al. (2001) EMBO J; 20 (3) : 457-465
Tang J, et al. (1999) Proc Natl Acad Sci U S A; 96 (17) : 9775-9780
Zhao Q, et al. (1996) Mol Cell Biol; 16 (12) : 6765-6774
Williams BL, et al. (1999) EMBO J; 18 (7) : 1832-1844
Adjali O, et al. (2005) J Clin Invest; 115 (8) : 2287-2295.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P43403

Host Species: Rabbit

Species Reactivity: Human, Mouse, Rat

Immunogen: Peptide sequence around aa.317~321 (S-P-Y-S-D) derived from Human ZAP70.

Immunogen Species: Human

Applications: ELISA, WB, IHC

Tested Applications: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:200

Purification Method: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:1000

Dilution Ratio3: IHC:1:50-1:200

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Immunology

Research Areas: Tags & Cell Markers;Immunology;Signal transduction