YTHDC1 Antibody | CSB-PA853467LA01HU

YTHDC1 Antibody | CSB-PA853467LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: YTHDC1

Aliases: YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B), YTHDC1, KIAA1966 YT521

Background: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A) -containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552) . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552) . Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937) . Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937) . In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937) . May also regulate alternative splice site selection (PubMed:20167602) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q96MU7

Host Species: Rabbit

Species Reactivity: Human, Mouse

Immunogen: Recombinant Human YTH domain-containing protein 1 protein (89-153AA)

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:1000-1:5000

Dilution Ratio3:

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling