UBE2O Antibody, FITC conjugated | CSB-PA866339LC01HU

UBE2O Antibody, FITC conjugated | CSB-PA866339LC01HU | Cusabio

UBE2O Antibody, FITC conjugated is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: UBE2O

Aliases: (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O), UBE2O, KIAA1734

Background: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950) . Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138) . Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153) . Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950) . Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853) .

Isotype: IgG

Conjugate: FITC

Clonality: Polyclonal

Uniport ID: Q9C0C9

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human (E3-independent) E2 ubiquitin-conjugating enzyme protein (10-277AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: Antigen Affinity Purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Cell biology