UBASH3A Antibody | CSB-PA785075

UBASH3A Antibody | CSB-PA785075 | Cusabio

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Product Type: Polyclonal Antibody

Target Names: UBASH3A

Aliases: Suppressor of T-cell receptor signaling 2; STS-2; Cbl-interacting protein 4; CLIP4; T-cell ubiquitin ligand

Background: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

Wattenhofer M., Hum. Genet. 108:140-147 (2001) .
Feshchenko E.A., Oncogene 23:4690-4706 (2004) .
Hattori M., Nature 405:311-319 (2000) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P57075

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Synthesized peptide derived from internal of human UBASH3A.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:3000

Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:3000

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Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Cell biology