Cusabio Polyclonal Antibodies
TUT1 Antibody | CSB-PA046708
- SKU:
- CSB-PA046708
- Availability:
- 3 to 7 Working Days
- Size:
- 100ul
Description
TUT1 Antibody | CSB-PA046708 | Cusabio
TUT1 Antibody is Available at Gentaur Genprice with the fastest delivery.
Online Order Payment is possible or send quotation to info@gentaur.com.
Product Type: Polyclonal Antibody
Target Names: TUT1
Aliases: U6 snRNA-specific terminal uridylyltransferase 1; EC 2.7.7.52; U6-TUTase; RNA-binding protein 21; RNA-binding motif protein 21
Background: Poly (A) polymerase that creates the 3'-poly (A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly (A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.
Ota T., Nat. Genet. 36:40-45 (2004) .
The MGC Project Team, Genome Res. 14:2121-2127 (2004) .
Trippe R., RNA 12:1494-1504 (2006) .
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: Q9H6E5
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Synthesized peptide derived from internal of human TUT1.
Immunogen Species: Human
Applications: ELISA, WB, IHC
Tested Applications: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100
Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: WB:1:500-1:3000
Dilution Ratio3: IHC:1:50-1:100
Dilution Ratio4:
Dilution Ratio5:
Dilution Ratio6:
Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Epigenetics and Nuclear Signaling
Research Areas: Epigenetics & Nuclear Signaling