Cusabio Polyclonal Antibodies
TRPM4 Antibody | CSB-PA819465ESR2HU
- SKU:
- CSB-PA819465ESR2HU
- Availability:
- 3 to 7 Working Days
Description
TRPM4 Antibody | CSB-PA819465ESR2HU | Cusabio
TRPM4 Antibody is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: TRPM4
Aliases: Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4), TRPM4, LTRPC4
Background: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca (2+), it is impermeable to it. Mediates transport of monovalent cations (Na (+) > K (+) > Cs (+) > Li (+) ), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca (2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca (2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: Q8TD43
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human Transient receptor potential cation channel subfamily M member 4 protein (1-240AA)
Immunogen Species: Human
Applications: ELISA, IHC
Tested Applications: ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Purification Method: Antigen Affinity Purified
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: IHC:1:20-1:200
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Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Neuroscience
Research Areas: Neuroscience;Cancer;Metabolism;Signal transduction