TRIB1 Antibody | CSB-PA836296LA01HU

TRIB1 Antibody | CSB-PA836296LA01HU | Cusabio

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Product Type: Polyclonal Antibody

Target Names: TRIB1

Aliases: Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1), TRIB1, C8FW GIG2 TRB1

Background: Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596) . The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797) . Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596) . Binds selectively the recognition sequence of CEBPA (PubMed:26455797) . Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2-dependent manner (By similarity) . Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity) . Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q96RU8

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Tribbles homolog 1 protein (3-91AA)

Immunogen Species: Human

Applications: ELISA, WB, IHC, IF

Tested Applications: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:5000

Dilution Ratio3: IHC:1:500-1:1000

Dilution Ratio4: IF:1:50-1:200

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Cardiovascular;Metabolism;Signal transduction;Stem cells