TP53 (Ab-46) Antibody | CSB-PA445446

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SKU:
CSB-PA445446
Availability:
3 to 7 Working Days
Size:
100ul
£388.88

Description

TP53 (Ab-46) Antibody | CSB-PA445446 | Cusabio

TP53 (Ab-46) Antibody is Available at Gentaur Genprice with the fastest delivery.

Online Order Payment is possible or send quotation to info@gentaur.com.

Product Type: Polyclonal Antibody

Target Names: TP53

Aliases: Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13

Background: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

Dhavan, R. and Tsai, L.H. (2001) Nat Rev Mol Cell Biol. 2: 749-759.
Patrick, G. N. et al. (1998) J Biol Chem. 273: 24057-24064.
Di Stefano V, et al. (2005) Oncogene. 24 (35) :5431-5442.
Mayo LD, et al. (2005) J Biol Chem. 280 (28) :25953-25959.
Wang L, et al. (2005) Oncogene. 24 (18) : 3020-3027.

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P04637

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Peptide sequence around aa. 44~48 (M-L-S-P-D) derived from Human p53.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:1000

Purification Method: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:1000

Dilution Ratio3:

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Dilution Ratio6:

Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Cell Biology

Research Areas: Epigenetics & Nuclear Signaling;Cancer;Cell biology

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