TNF Monoclonal Antibody | CSB-MA084771A0m

TNF Monoclonal Antibody | CSB-MA084771A0m | Cusabio

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Product Type: Monoclonal Antibody

Target Name: TNF

Aliases: Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2

Relevance: Tumor necrosis factor alpha (TNFα, also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNFα is produced by a wide variety of immune and epithelial cell types. Bovine TNFα consisits of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 178 aa extracellular domain (ECD) . Within the ECD, bovine TNFα shares 64%-83% sequence identity with canine, cotton rat, equine, feline, human, mouse, porcine, rat, and rhesus TNFα.The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness. Cleavage of membrane bound TNFα by TACE/ADAM17 releases a 55 kDa soluble trimeric form of TNFα. TNFα trimers bind the ubiquitous TNF RI and the hematopoietic cell restricted TNF RII, both of which are also expressed as homotrimers. TNFα regulates lymphoid tissue development through control of apoptosis. It also promotes inflammatory responses by inducing the activation of vascular endothelial cells and macrophages. TNFα is a key cytokine in several inflammatory disorders. It contributes to the development of type 2 diabetes through its effects on insulin resistance and fatty acid metabolism.

Isotype: IgG2b

Conjugate: Non-conjugated

Clone Number: 2E1A5

Uniport ID: Q06599

Alternatives To SCBT: #N/A

Host Species: Mouse

Species Reactivity: Bovine

Immunogen: Recombinant Bovine TNF alpha protein

Immunogen Species: Bovine

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Others

Research Areas: Others