TNF Antibody | CSB-PA147864

TNF Antibody | CSB-PA147864 | Cusabio

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Product Type: Polyclonal Antibody

Target Names: TNF

Aliases: Protein name Tumor necrosis factor [Precursor]; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin

Background: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

Neville M.J., J. Immunol. 162:4745-4754 (1999) .
Xie T., Genome Res. 13:2621-2636 (2003) .
Kim Y.J., Hum. Mol. Genet. 12:2541-2546 (2003) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: P01375

Host Species: Rabbit

Species Reactivity: Human, Mouse

Immunogen: Synthesized peptide derived from internal of human TNFA.

Immunogen Species: Human

Applications: ELISA, IHC, IF

Tested Applications: ELISA, IHC, IF;IHC:1:50-1:100, IF:1:100-1:500

Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: IHC:1:50-1:100

Dilution Ratio3: IF:1:100-1:500

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Immunology

Research Areas: Cancer;Cardiovascular;Immunology;Metabolism;Signal transduction