TLK1 Antibody | CSB-PA178566

TLK1 Antibody | CSB-PA178566 | Cusabio

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Product Type: Polyclonal Antibody

Target Names: TLK1

Aliases: kinase TLK1; PKU-beta; tousled-like kinase 1;

Background: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

Yamakawa A., Gene 202:193-201 (1997) .
Sillje H.H.W., EMBO J. 18:5691-5702 (1999) .
Cabaniols J.-P., Mol. Biol. Cell 10:4033-4041 (1999) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q9UKI8

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Synthesized peptide derived from internal of human TLK1.

Immunogen Species: Human

Applications: ELISA, WB

Tested Applications: ELISA, WB;WB:1:500-1:3000

Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:3000

Dilution Ratio3:

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Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Epigenetics and Nuclear Signaling

Research Areas: Epigenetics & Nuclear Signaling;Signal transduction