Cusabio Polyclonal Antibodies
TCIM Antibody | CSB-PA882079ESR1HU
- SKU:
- CSB-PA882079ESR1HU
- Availability:
- 3 to 7 Working Days
Description
TCIM Antibody | CSB-PA882079ESR1HU | Cusabio
TCIM Antibody is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: TCIM
Aliases: Transcriptional and immune response regulator (Thyroid cancer protein 1) (TC-1), TCIM, C8orf4 TC1
Background: Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711) . Enhances the proliferation of follicular dendritic cells (PubMed:16730711) . Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821) . In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084) . Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013) . Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity) . In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347) . However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737) .
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: Q9NR00
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human Transcriptional and immune response regulator protein (1-106AA)
Immunogen Species: Human
Applications: ELISA, IHC
Tested Applications: ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Purification Method: Antigen Affinity Purified
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: IHC:1:20-1:200
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Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Signal Transduction
Research Areas: Epigenetics & Nuclear Signaling;Cancer;Signal transduction;Stem cells