SPPL2B Antibody, Biotin conjugated | CSB-PA823457LD01HU

SPPL2B Antibody, Biotin conjugated | CSB-PA823457LD01HU | Cusabio

SPPL2B Antibody, Biotin conjugated is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: SPPL2B

Aliases: Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1), SPPL2B, IMP4 KIAA1532 PSL1

Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595) . Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951) . May play a role in the regulation of innate and adaptive immunity (PubMed:16829952) . Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC) -mediated cleavage proteolysis (PubMed:23132852) .

Isotype: IgG

Conjugate: Biotin

Clonality: Polyclonal

Uniport ID: Q8TCT7

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Signal peptide peptidase-like 2B protein (492-592AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Others

Research Areas: Others