Socs3 Antibody | CSB-PA022392LA01RA

Socs3 Antibody | CSB-PA022392LA01RA | Cusabio

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Product Type: Polyclonal Antibody

Target Names: Socs3

Aliases: Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3), Socs3, Cish3

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: O88583

Host Species: Rabbit

Species Reactivity: Rat, Human

Immunogen: Recombinant Rat Suppressor of cytokine signaling 3 protein (1-225AA)

Immunogen Species: Rat

Applications: ELISA, WB

Tested Applications: ELISA, WB; Recommended dilution: WB:1:500-1:2000

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:2000

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Immunology

Research Areas: Epigenetics & Nuclear Signaling;Cancer;Immunology;Metabolism;Signal transduction;Stem cells