SNX6 Antibody | CSB-PA890766LA01HU

SNX6 Antibody | CSB-PA890766LA01HU | Cusabio

SNX6 Antibody is Available at Gentaur Genprice with the fastest delivery.

Online Order Payment is possible or send quotation to info@gentaur.com.

Product Type: Polyclonal Antibody

Target Names: SNX6

Aliases: Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed], SNX6

Background: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3, 4-bisphosphate and/or phosphatidylinositol 4, 5-bisphosphate (Probable) . Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774) . The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable) . Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988) . Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574) . May function as link between transport vesicles and dynactin (Probable) . Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142) . Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942) . In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity) . May contribute to transcription regulation (Probable) .

Isotype: IgG

Conjugate: Non-conjugated

Clonality: Polyclonal

Uniport ID: Q9UNH7

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Sorting nexin-6 protein (1-290AA)

Immunogen Species: Human

Applications: ELISA, WB, IHC

Tested Applications: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Purification Method: >95%, Protein G purified

Dilution Ratio1: ELISA:1:2000-1:10000

Dilution Ratio2: WB:1:500-1:2000

Dilution Ratio3: IHC:1:20-1:200

Dilution Ratio4:

Dilution Ratio5:

Dilution Ratio6:

Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Others

Research Areas: Others