SMAD2 Monoclonal Antibody | CSB-MA913719

SMAD2 Monoclonal Antibody | CSB-MA913719 | Cusabio

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Product Type: Monoclonal Antibody

Target Name: SMAD2

Aliases: hMAD 2; hMAD-2; hSMAD2; JV18 1; JV18; JV18; JV18-1; JV181; MAD; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mothers Against Decapentaplegic Homolog 2; Mothers Against Decapentaplegic Homolog 2;

Relevance: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription.May act as a tumor suppressor in colorectal carcinoma.Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Isotype: IgG1

Conjugate: Non-conjugated

Clone Number:

Uniport ID: Q15796

Alternatives To SCBT:

Host Species: Mouse

Species Reactivity: Human

Immunogen: Purified recombinant human SMAD2 protein fragments expressed in E.coli.

Immunogen Species: Human

Applications: ELISA, WB, ICC

Tested Applications: ELISA, WB, ICC;Recommended dilution:WB:1:500-1:5000, ICC:1:50-1:200

Purification Method: Affinity purified

Dilution Ratio1: WB:1:500-1:5000

Dilution Ratio2: ICC:1:50-1:200

Dilution Ratio3:

Dilution Ratio4:

Dilution Ratio5:

Buffer: Ascites

Form: liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Epigenetics and Nuclear Signaling;Cancer;Metabolism;Signal transduction;Stem cells