SKP2 Antibody | CSB-RA224072A0HU
- 3 to 7 Working Days
SKP2 Antibody | CSB-RA224072A0HU | Cusabio
SKP2 Antibody is Available at Gentaur Genprice with the fastest delivery.
Online Order Payment is possible or send quotation to email@example.com.
Antibody Type: Recombinant
Target Names: SKP2
Aliases: S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2), SKP2, FBXL1
Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
Isotype: Rabbit IgG
Clone Number: 6D4
Uniport ID: Q13309
Modified: Cancer; Cardiovascular; Cell biology
species: Homo sapiens (Human)
Species Reactivity: Human
Immunogen: A synthesized peptide derived from human SKP2
Tested Applications: ELISA, IHC, IF; Recommended dilution: IHC:1:50-1:200, IF:1:20-1:200
Purification Method: Affinity-chromatography
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.