Cusabio Polyclonal Antibodies
SIRPA Antibody | CSB-PA973893
- SKU:
- CSB-PA973893
- Availability:
- 3 to 7 Working Days
- Size:
- 100ul
Description
SIRPA Antibody | CSB-PA973893 | Cusabio
SIRPA Antibody is Available at Gentaur Genprice with the fastest delivery.
Online Order Payment is possible or send quotation to info@gentaur.com.
Product Type: Polyclonal Antibody
Target Names: SIRPA
Aliases: Bit; MFR; MYD-1 antigen; MYD1; Macrophage fusion receptor
Background: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Kentaro Ide, PNAS, Mar 2007; 104: 5062 - 5066.
Thomas T. Chen, Cancer Res., Jan 2004; 64: 117 - 127.
Shu Q. Liu, J. Biol. Chem., Nov 2005; 280: 39294 - 39301.
Gurpreet S. Kapoor, Cancer Res., Sep 2004; 64: 6444 - 6452.
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: P78324
Host Species: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human SIRP-alpha1.
Immunogen Species: Human
Applications: ELISA, WB, IHC
Tested Applications: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100
Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: WB:1:500-1:3000
Dilution Ratio3: IHC:1:50-1:100
Dilution Ratio4:
Dilution Ratio5:
Dilution Ratio6:
Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form: liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Neuroscience
Research Areas: Neuroscience;Cardiovascular;Signal transduction