SETX Antibody, FITC conjugated | CSB-PA800097LC01HU

SETX Antibody, FITC conjugated | CSB-PA800097LC01HU | Cusabio

SETX Antibody, FITC conjugated is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: SETX

Aliases: Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin), SETX, ALS4 KIAA0625 SCAR1

Background: Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224) . Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850) . Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly (A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224) . Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity) . Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789) . In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744) . Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity) . May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256) . Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111) .

Isotype: IgG

Conjugate: FITC

Clonality: Polyclonal

Uniport ID: Q7Z333

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human Probable helicase senataxin protein (2401-2677AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Neuroscience

Research Areas: Epigenetics & Nuclear Signaling;Neuroscience