SARS Antibody, Biotin conjugated | CSB-PA04145D0Rb
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SARS Antibody, Biotin conjugated | CSB-PA04145D0Rb | Cusabio
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Product Type: Polyclonal Antibody
Target Names: SARS
Aliases: Serine--tRNA ligase, cytoplasmic (EC 220.127.116.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA (Ser/Sec) synthetase), SARS, SERS
Background: Catalyzes the attachment of serine to tRNA (Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA (Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339) . Is probably also able to aminoacylate tRNA (Sec) with serine, to form the misacylated tRNA L-seryl-tRNA (Sec), which will be further converted into selenocysteinyl-tRNA (Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339) . In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000) . Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16) . Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000) .
Uniport ID: P49591
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human Serine--tRNA ligase, cytoplasmic protein (2-233AA)
Immunogen Species: Human
Tested Applications: ELISA
Purification Method: >95%, Protein G purified
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Epigenetics and Nuclear Signaling
Research Areas: Epigenetics & Nuclear Signaling