RNF20 Antibody | CSB-RA227095A0HU
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RNF20 Antibody | CSB-RA227095A0HU | Cusabio
RNF20 Antibody is Available at Gentaur Genprice with the fastest delivery.
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Antibody Type: Recombinant
Target Names: RNF20
Aliases: E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 18.104.22.168) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A), RNF20, BRE1A
Background: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
Isotype: Rabbit IgG
Clone Number: 2H12
Uniport ID: Q5VTR2
Modified: Cell biology
species: Homo sapiens (Human)
Species Reactivity: Human
Immunogen: A synthesized peptide derived from human RNF20
Tested Applications: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200
Purification Method: Affinity-chromatography
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.