Ripk1 Antibody, FITC conjugated | CSB-PA720181LC01MO
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Ripk1 Antibody, FITC conjugated | CSB-PA720181LC01MO | Cusabio
Ripk1 Antibody, FITC conjugated is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: Ripk1
Aliases: Receptor-interacting serine/threonine-protein kinase 1 (EC 184.108.40.206) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) (Serine/threonine-protein kinase RIP), Ripk1, Rinp Rip
Background: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (By similarity) . Interacts with ARHGEF2 (By similarity) .
Uniport ID: Q60855
Host Species: Rabbit
Species Reactivity: Mouse
Immunogen: Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 protein (1-656AA)
Immunogen Species: Mouse
Tested Applications: ELISA
Purification Method: >95%, Protein G purified
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Cell Biology
Research Areas: Cancer;Cell biology;Signal transduction