Recombinant Rat Vitamin K-dependent protein C (Proc) | CSB-YP018742RA

Recombinant Rat Vitamin K-dependent protein C (Proc) | CSB-YP018742RA | Cusabio

Alternative Name(s): Anticoagulant protein C Autoprothrombin IIA Blood coagulation factor XIV

Gene Names: Proc

Research Areas: Cardiovascular

Organism: Rattus norvegicus (Rat)

AA Sequence: ANSFLEEVRAGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSTPPLDHQCDSPCCGHGTCIDGLGGFSCSCDKGWEGRFCQQEMGFQDCRVKNGGCYHYCLEETRGRRCRCAPGYELADDHMHCRPTVNFPCGKLWKRTDKKRKNFKRDIDPEDEELELGPRIVNGTLTKQGDSPWQAILLDSKKKLACGGVLIHTSWVLTAAHCLESSKKLTVRLGEYDLRRRDPWELDLDIKEVLVHPNYTRSNSDNDIALLRLSQPATLSKTIVPICLPNSGLAQELSQAGQETVVTGWGYQSDKVKDGRRNRTFILTFIRIPLAARNDCMQVMNNVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHLNNYGVYTKVGSYLKWIHSYIGERDVSLKSPKL

Source: Yeast

Tag Info: N-terminal 6xHis-tagged

Expression Region: 42-461aa

Sequence Info: Full Length of Mature Protein

MW: 49.3 kDa

Purity: Greater than 85% as determined by SDS-PAGE.

Relevance: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.

Reference: "Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis." Heuer J.G., Sharma G.R., Gerlitz B., Zhang T., Bailey D.L., Ding C., Berg D.T., Perkins D., Stephens E.J., Holmes K.C., Grubbs R.L., Fynboe K.A., Chen Y.F., Grinnell B., Jakubowski J.A. Crit. Care Med. 32:1570-1578(2004)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.

Involvement in disease:

Subcellular Location: Secreted, Golgi apparatus, Endoplasmic reticulum

Protein Families: Peptidase S1 family

Tissue Specificity: Plasma; synthesized in the liver.

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P31394

HGNC Database Link: N/A

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: N/A