Recombinant Rat Cardiotrophin-1 protein (Ctf1) (Active) | CSB-AP000211RA

Recombinant Rat Cardiotrophin-1 protein (Ctf1) (Active) | CSB-AP000211RA | Cusabio

Protein Description: Full Length

Alternative Name (s) : CT-1,

Gene Names: Ctf1

Research Areas: Immunology

Species: Rattus norvegicus (Rat)

Source: E.Coli

Tag Info: Tag-Free

Expression Region: 1-203aa

Sequence Info: MSQREGSLED HQTDSSFSFL PHLEAKIRQT HNLARLLTKY ADQLLEEYVQ QQGEPFGLPG FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSALPAL LDAVRRRQAE LNPRAPRLLR SLEDAARQVR ALGAAVETVL AALGAAARGP VPEPVATSAL FTSNSAAGVF SAKVLGLHVC GLYGEWVSRT EGDLGQLVPG GVA

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.5 ng/ml, corresponding to a specific activity of ＞ 2.0 × 106 IU/mg.

MW: 21.4 kDa

Purity: >95% as determined by SDS-PAGE and HPLC.

Endotoxin: Less than 1.0 EU/µg as determined by LAL method.

Relevance: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

PubMed ID: 8604995; 15489334

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Function: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Involvement in disease:

Subcellular Location: Secreted

Protein Families: IL-6 superfamily

Tissue Specificity: Expressed in the ventricle and atrium of adult rats. Also detected in the lung, kidney, liver, skeletal muscle, stomach and urinary bladder. Not detected in brain, colon, testis, spleen or thymus. Overexpressed in the ventricles in the case of hypertension and hypertrophy.

Paythway:

Form: Lyophilized powder

Buffer: Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 150mM NaCl

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: Q63086

Uniprot Entry Name: CTF1_RAT

HGNC Database Link: N/A

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: N/A